Jp En

Publication

Articiles

Articiles

*corresponding author
2024

  • Takashima Y, Okubo T

    Embryo model made using pluripotent stem cells reveals details of early development in humans
    Nature 2024; Jan 31 https://doi.org/10.1038/d41586-023-04114-y (2024)

  • Kunitomi A, Hirohata R, Osawa M, Washizu K, Arreola V, Saiki1 N, Kato T, Nomura M, Kunitomi H, Ohkame T, Ohkame Y, Kawaguchi J, Hara H, Kusano K, Yamamoto Y, Takashima Y, Tohyama S, Yuasa S, Fukuda K, Takasu N, Yamanaka S

    H1FOO-DD promotes efficiency and uniformity in reprogramming to naive pluripotency
    Stem Cell Reports 2024; doi: 10.1016/j.stemcr.2024.04.005
2023

  • Shono M, Kishimoto K, Hikabe O, Hayashi M, Semi K, Takashima Y, Sasaki E, Kato K, Hayashi K..

    Induction of primordial germ cell-like cells from common marmoset embryonic stem cells by inhibition of WNT and retinoic acid signaling.
    Sci Rep 2023; 13 DOI: 10.1038/s41598-023-29850-z

  • Kubiura-Ichimaru M, Penfold C, Kojima K, Dollet C, Yabukami H, Semi K, Takashima Y, Boroviak T, Kawaji H, Woltjen K, Minoda A, Sasaki E, Watanabe T

    mRNA-based generation of marmoset PGCLCs capable of differentiation into gonocyte-like cells
    Stem Cell Reports 2023; Oct 1018(10):1987-2002. doi: 10.1016/j.stemcr.2023.08.006. Epub 2023 Sep 7.PMID: 37683645

  • Suzuki D, Lan KC,Takashima Y

    Using human pluripotent stem cells to dissect trophoblast development
    Curr Opin Genet Dev 2023; Oct 783:102126.PMID: 37812907 doi: 10.1016/j.gde.2023.102126

  • Okubo T, Rivron N, Kabata M, Masaki H, Kishimoto K, Semi K, Nakajima-Koyama M, Kunitomi H, Kaswandy B, Sato H, Nakauchi H, Woltjen K, Saitou M, Sasaki E, Yamamoto T, Takashima Y

    Hypoblast from human pluripotent stem cells regulates epiblast development
    Nature, 2023 Dec 5. doi: 10.1038/s41586-023-06871-2 2023; Dec 5 doi: 10.1038/s41586-023-06871-2
2022

  • Kunitomi A, Hirohata R, Arreola V, Osawa M, Tomoaki M. Kato, Nomura M, Kawaguchi J, Hara H, Kusano K, Takashima Y, Takahashi K, Fukuda K, Takasu N, Yamanaka S.

    Improved Sendai viral system for reprogramming to naive pluripotency.
    Cell Reports Methods 2022; doi: https://doi.org/10.1016/j.crmeth.2022.100317

  • Okubo T, Takashima Y*.

    Exploring the human extraembryonic mesoderm using naive pluripotent stem cells.
    Cell Stem Cell 2022; 29(9)1290-1291 DOI: 10.1016/j.stem.2022.08.005
2021

  • Io S, Iemura Y, Takashima Y*.

    Optimized protocol for naive human pluripotent stem cell-derived trophoblast induction.
    STAR Protocols 2021; 2(4)100921 DOI: 10.1016/j.xpro.2021.100921

  • Kishimoto K, Shimada A, Shinohara H, Takahashi T, Yamada Y, Higuchi Y, Yoneda N, Suemizu H, Kawai K, Kurotaki Y, Hanazawa K, Takashima Y, Sasaki E.

    Establishment of novel common marmoset embryonic stem cell lines under various conditions.
    Stem Cell Res 2021; 53102252 DOI: 10.1016/j.scr.2021.102252

  • Takahashi K, Nakamura M, Okubo C, Kliesmete Z, Ohnuki M, Narita M, Watanabe A Ueda M, Takashima Y, Hellmann I, Yamanaka S.

    The pluripotent stem cell-specific transcript ESRG is dispensable for human pluripotency.
    PLoS Genet 2021; 17(5)e1009587 DOI: 10.1371/journal.pgen.1009587

  • Io S., Kabata M., Iemura Y., Semi K., Morone N., Minagawa A., Wang B., Okamoto I., Nakamura T., Kojima Y., Iwatani C., Tsuchiya H., Kaswandy B., Kondoh E., Kaneko S., Woltjen K., Saitou M., Yamamoto T., Mandai M., Takashima Y*.

    Capturing human trophoblast development with naive pluripotent stem cells in vitro.
    Cell Stem Cell 2021; 28(6)1023-1039 DOI: 10.1016/j.stem.2021.03.013

  • Semi K., and Takashima Y*.

    Pluripotent stem cells for the study of early human embryology.
    Dev Growth Differ 2021; 63104-115 DOI: 10.1111/dgd.12715
2019

  • Huang M, Tailor J, Zhen Q, Gillmor AH, Miller ML, Weishaupt H, Chen J, Zheng T, Nash EK, McHenry LK, An Z, Ye F, Takashima Y, Clarke J, Ayetey H, Cavalli FMG, Luu B, Moriarity BS, Ilkhanizadeh S, Chavez L, Yu C, Kurian KM, Magnaldo T, Sevenet N, Koch P, Pollard SM, Dirks P, Snyder MP, Largaespada DA, Cho YJ, Phillips JJ, Swartling FJ, Morrissy AS, Kool M, Pfister SM, Taylor MD, Smith A, Weiss WA.

    Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis.
    Cell Stem Cell 2019; 25(3)433-446 DOI:10.1016/j.stem.2019.05.013
2018

  • Stefano BD, Ueda M, Sabri S, Brumbaugh J, Huebner A, Sahakyan A, Clement K, Clowers KJ, Erickson A, Shioda K, Gygi SP, Gu H, Shioda T, MeissnerA, Takashima Y, Plath K, Hochedlinger K.

    Reduced MEK inhibition confers a growth advantage and improves genomic stability in naïve human ES cells.
    Nature Methods 2018; 15(9)732-740 DOI: 10.1038/s41592-018-0104-1

  • Yu L, Li J, Hong J, Takashima Y, Fujimoto N, Nakajima M, Yamamoto A, Dong X, Dang Y, Hou Y, Yang W, Minami I, Okita K, Tanaka M, Luo C, Tang F, Chen Y, Tang C, Kotera H, Liu L.

    Low Cell-Matrix Adhesion Reveals Two Subtypes of Human Pluripotent Stem Cells.
    Stem Cell Reports 2018; 11(1)142-156 DOI: 10.1016/j.stemcr.2018.06.003
2017

  • Karagiannis P, Takashima Y*.

    Surface markers guide the journey towards naïve pluripotency
    Cell Stem Cell 2017; 20(6)237-238 DOI:10.1016/j.stem.2017.05.004

  • Honda A, Kawano Y, Izu H, Choijookhuu N, Honsho K, Nakamura T, Yabuta Y, Yamamoto T, Takashima Y, Hirose M, Sankai T, Hishikawa Y, Ogura A, Saitou M.

    Discrimination of Stem Cell Status after Subjecting Cynomolgus Monkey Pluripotent Stem Cells to Naïve Conversion.
    Sci Rep 2017; 28(7)45285 doi: 10.1038/srep45285
2014

  • Takashima Y, Guo G, Loos R, Nichols J, Ficz G, Krueger F, Oxley D, Santos F, Clarke J, Mansfield W, Reik W, Bertone P and Smith A.

    Resetting transcription factor control circuitry towards ground state pluripotency in human.
    Cell 2014; 158(6)1254–69 DOI: 10.1016/j.cell.2015.06.052

  • Mohsen-Kanson T, Hafner AL, Wdziekonski B, Takashima Y, Villageois P, Carrière A, Svensson M, Bagnis C, Chignon-Sicard B, Svensson PA, Casteilla L, Smith A and Dani C.

    Differentiation of human induced pluripotent stem cells into brown and white adipocytes: Role of Pax3.
    Stem Cells 2014; 32(6)1459-67 doi.org/10.1002/stem.1607

  • Kojima G, Ishida K, Takashima Y, Kurata H, Sasae R, Takaya Y.

    Rhabdomyolysis-induced transient cold urticaria.
    Ann Allergy Asthma Immunol 2014; 113(5)572-4
2013

  • Stricker S, Feber A, Engstrom PG, Caren H, Kurian KM, Takashima Y, Watts C, Way M, Dirks P, Bertone P, Smith A, Beck S, and Pollard SM.

    Widespread resetting of DNA methylation in glioblastoma-initiating cells suppresses malignant cellular behavior in a lineage-dependent manner.
    Genes and Dev 2013; 27(6)654–69
2012

  • Falk A, Koch P, Kesavan J, Takashima Y, Ladewig J, Alexander M, Wiskow O, Tailor J, Trotter T, Pollard S, Smith A, Brüstle O.

    Capture of neuroepithelial-like stem cells from pluripotent stem cells provides a versatile system for in vitro production of human neurons.
    PLOS ONE 2012; 7e29597

  • Camnasio S, Carri DA, Lombardo A, Grad I, Mariotti C, Castucci A, Rozell B, Riso PL, Castiglioni V, Zuccato C, Rochon C, Takashima Y, Diaferia G, Biunno I, Gellera C, Jaconi M, Smith A, Hovatta O, Naldini L, Donato SD, Feki A, Cattaneo E.

    The first reported generation of several induced pluripotent stem cell lines from homozygous and heterozygous Huntington's disease patients demonstrates mutation related enhanced lysosomal activity.
    Neurobiol Dis 2012; 46(1)41-51
2011

  • Nagare T, Sakaue H, Matsumoto M, Cao Y, Inagaki K, Sakai M, Takashima Y, Nakamura K, Mori T, Okada Y, Matsuki Y, Watanabe E, Ikeda K, Taguchi R, Kamimura N, Ohta S, Hiramatsu R, Kasuga M.

    Overexpression of KLF15 Transcription Factor in Adipocytes of Mice Results in Down-regulation of SCD1 Protein Expression in Adipocytes and Consequent Enhancement of Glucose-induced Insulin Secretion.
    J Biol Chem. 2011; 286(43)37458-69
2010

  • Moretti A, Bellin M, Jung CB, Thies TM, Takashima Y, Bernshausen A, Schiemann M, Fischer S, Moosmang S, Smith AG, Lam JT, Laugwitz KL.

    Mouse and human induced pluripotent stem cells as a source for multipotent Isl1+ cardiovascular progenitors.
    FASEB J. 2010; 24(3)700-11

  • Zaragosi LE, Wdziekonski B, Villageois P, Keophiphath M, Maumus M, Tchkonia T, Bourlier V, Mohsen-Kanson T, Ladoux A, Elabd C, Scheideler M, Trajanoski Z, Takashima Y, Amri EZ, Lacasa D, Sengenes C, Ailhaud G, Clément K, Bouloumie A, Kirkland JL, Dani C.

    Activin a plays a critical role in proliferation and differentiation of human adipose progenitors.
    Diabetes 2010; 59(10)2513-21
2007

  • Takashima Y, Era T, Nakao K, Kondo S, Kasuga K, Smith AG, Nishikawa S.

    Neuroepithelial cells supply an initial transient wave of MSC differentiation.
    Cell 2007; 129(7)1377 -88

  • Hikichi T, Wakayama S, Mizutani E, Takashima Y, Kishigami S, Van Thuan N, Ohta H, Bui HT, Nishikawa SI, Wakayama T.

    Differentiation Potential of Parthenogenetic Embryonic Stem Cells is Improved by Nuclear Transfer.
    Stem Cells. 2007; 25(1)46-53
2005

  • Mori T, Sakaue H, Iguchi H, Gomi H, Okada Y, Takashima Y, Nakamura K, Nakamura T, Yamauchi T, Kubota N, Kadowaki T, Matsuki Y, Ogawa W, Hiramatsu R, Kasuga M.

    Role of Kruppel-like factor 15 (KLF15) in transcriptional regulation of adipogenesis.
    J Biol Chem. 2005; 280(13)12867-75
2003

  • Sakaue H, Nishizawa A, Ogawa W, Teshigawara K, Mori T, Takashima Y, Noda T, Kasuga M.

    Requirement for 3-phosphoinositide-kependent dinase-1 (PDK-1) in insulin-induced glucose uptake in immortalized brown adipocytes.
    J Biol Chem. 2003; 278(40)38870-4
2002

  • Takashima Y*, Koide M, Fukunaga H, Iwai M, Miura M, Yoneda R, Fukuda T, Kobayashi K, Saheki T.

    Recovery from marked altered consciousness in a patient with adult-onset type II citrullinemia diagnosed by DNA analysis and treated with a living related partial liver transplantation.
    Intern Med. 2002; 41(7)555-60