Jp En

Publication

発表論文 著作物

発表論文

*corresponding author
2024

  • Kunitomi A, Hirohata R, Osawa M, Washizu K, Arreola V, Saiki1 N, Kato T, Nomura M, Kunitomi H, Ohkame T, Ohkame Y, Kawaguchi J, Hara H, Kusano K, Yamamoto Y, Takashima Y, Tohyama S, Yuasa S, Fukuda K, Takasu N, Yamanaka S

    H1FOO-DD promotes efficiency and uniformity in reprogramming to naive pluripotency. Stem Cell Reports
    Stem Cell Reports 2024; doi: 10.1016/j.stemcr.2024.04.005

  • Takashima Y, Okubo T

    Embryo model made using pluripotent stem cells reveals details of early development in humans
    Nature 2024; doi.org/10.1038/d41586-023-04114-y

  • Asako Inohaya, Yoshitsugu Chigusa, Masahito Takakura, Shingo Io, Min-A Kim, Yu Matsuzaka, Eriko Yasuda, Yusuke Ueda, Yosuke Kawamura, Shiro Takamatsu, Haruta Mohami, Yasuhiro Takashima, Masaki Mandai and Eiji Kondoh

    Shear stress in the intervillous space promotes syncytial formation of iPS cells-derived trophoblasts
    Biology of Reproduction 2024; 110(2), 300-309 https://doi.org/10.1093/biolre/ioad143
2023

  • Okubo T, Rivron N, Kabata M, Masaki H, Kishimoto K, Semi K, Nakajima-Koyama M, Kunitomi H, Kaswandy B, Sato H, Nakauchi H, Woltjen K, Saitou M, Sasaki E, Yamamoto T, Takashima Y*.

    Hypoblast from human pluripotent stem cells regulates epiblast development
    Nature 2023; doi: 10.1038/s41586-023-06871-2

  • Suzuki D, Lan KC, Takashima Y.

    Using human pluripotent stem cells to dissect trophoblast development.
    Curr Opin Genet Dev 2023; 83102126 DOI: 10.1016/j.gde.2023.102126

  • Kubiura-Ichimaru M, Penfold C, Kojima K, Dollet C, Yabukami H, Semi K, Takashima Y, Boroviak T, Kawaji H, Woltjen K, Minoda A, Sasaki E, Watanabe T.

    mRNA-based generation of marmoset PGCLCs capable of differentiation into gonocyte-like cells.
    Stem Cell Reports 2023; 18 DOI: 10.1016/j.stemcr.2023.08.006

  • Shono M, Kishimoto K, Hikabe O, Hayashi M, Semi K, Takashima Y, Sasaki E, Kato K, Hayashi K..

    Induction of primordial germ cell-like cells from common marmoset embryonic stem cells by inhibition of WNT and retinoic acid signaling.
    Sci Rep 2023; 13 DOI: 10.1038/s41598-023-29850-z
2022

  • Kunitomi A, Hirohata R, Arreola V, Osawa M, Tomoaki M. Kato, Nomura M, Kawaguchi J, Hara H, Kusano K, Takashima Y, Takahashi K, Fukuda K, Takasu N, Yamanaka S.

    Improved Sendai viral system for reprogramming to naive pluripotency.
    Cell Reports Methods 2022; doi: https://doi.org/10.1016/j.crmeth.2022.100317

  • Okubo T, Takashima Y*.

    Exploring the human extraembryonic mesoderm using naive pluripotent stem cells.
    Cell Stem Cell 2022; 29(9)1290-1291 DOI: 10.1016/j.stem.2022.08.005
2021

  • Io S, Iemura Y, Takashima Y*.

    Optimized protocol for naive human pluripotent stem cell-derived trophoblast induction.
    STAR Protocols 2021; 2(4)100921 DOI: 10.1016/j.xpro.2021.100921

  • Kishimoto K, Shimada A, Shinohara H, Takahashi T, Yamada Y, Higuchi Y, Yoneda N, Suemizu H, Kawai K, Kurotaki Y, Hanazawa K, Takashima Y, Sasaki E.

    Establishment of novel common marmoset embryonic stem cell lines under various conditions.
    Stem Cell Res 2021; 53102252 DOI: 10.1016/j.scr.2021.102252

  • Takahashi K, Nakamura M, Okubo C, Kliesmete Z, Ohnuki M, Narita M, Watanabe A Ueda M, Takashima Y, Hellmann I, Yamanaka S.

    The pluripotent stem cell-specific transcript ESRG is dispensable for human pluripotency.
    PLoS Genet 2021; 17(5)e1009587 DOI: 10.1371/journal.pgen.1009587

  • Io S., Kabata M., Iemura Y., Semi K., Morone N., Minagawa A., Wang B., Okamoto I., Nakamura T., Kojima Y., Iwatani C., Tsuchiya H., Kaswandy B., Kondoh E., Kaneko S., Woltjen K., Saitou M., Yamamoto T., Mandai M., Takashima Y*.

    Capturing human trophoblast development with naive pluripotent stem cells in vitro.
    Cell Stem Cell 2021; 28(6)1023-1039 DOI: 10.1016/j.stem.2021.03.013

  • Semi K., and Takashima Y*.

    Pluripotent stem cells for the study of early human embryology.
    Dev Growth Differ 2021; 63104-115 DOI: 10.1111/dgd.12715
2019

  • Huang M, Tailor J, Zhen Q, Gillmor AH, Miller ML, Weishaupt H, Chen J, Zheng T, Nash EK, McHenry LK, An Z, Ye F, Takashima Y, Clarke J, Ayetey H, Cavalli FMG, Luu B, Moriarity BS, Ilkhanizadeh S, Chavez L, Yu C, Kurian KM, Magnaldo T, Sevenet N, Koch P, Pollard SM, Dirks P, Snyder MP, Largaespada DA, Cho YJ, Phillips JJ, Swartling FJ, Morrissy AS, Kool M, Pfister SM, Taylor MD, Smith A, Weiss WA.

    Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis.
    Cell Stem Cell 2019; 25(3)433-446 DOI:10.1016/j.stem.2019.05.013
2018

  • Stefano BD, Ueda M, Sabri S, Brumbaugh J, Huebner A, Sahakyan A, Clement K, Clowers KJ, Erickson A, Shioda K, Gygi SP, Gu H, Shioda T, MeissnerA, Takashima Y, Plath K, Hochedlinger K.

    Reduced MEK inhibition confers a growth advantage and improves genomic stability in naïve human ES cells.
    Nature Methods 2018; 15(9)732-740 DOI: 10.1038/s41592-018-0104-1

  • Yu L, Li J, Hong J, Takashima Y, Fujimoto N, Nakajima M, Yamamoto A, Dong X, Dang Y, Hou Y, Yang W, Minami I, Okita K, Tanaka M, Luo C, Tang F, Chen Y, Tang C, Kotera H, Liu L.

    Low Cell-Matrix Adhesion Reveals Two Subtypes of Human Pluripotent Stem Cells.
    Stem Cell Reports 2018; 11(1)142-156 DOI: 10.1016/j.stemcr.2018.06.003

  • 髙島　康弘

    iPS細胞の樹立と新たな生命科学の開拓
    Aging Science 2018; 1195-98
2017

  • Karagiannis P, Takashima Y*.

    Surface markers guide the journey towards naïve pluripotency
    Cell Stem Cell 2017; 20(6)237-238 DOI:10.1016/j.stem.2017.05.004

  • Honda A, Kawano Y, Izu H, Choijookhuu N, Honsho K, Nakamura T, Yabuta Y, Yamamoto T, Takashima Y, Hirose M, Sankai T, Hishikawa Y, Ogura A, Saitou M.

    Discrimination of Stem Cell Status after Subjecting Cynomolgus Monkey Pluripotent Stem Cells to Naïve Conversion.
    Sci Rep 2017; 28(7)45285 doi: 10.1038/srep45285
2014

  • Takashima Y, Guo G, Loos R, Nichols J, Ficz G, Krueger F, Oxley D, Santos F, Clarke J, Mansfield W, Reik W, Bertone P and Smith A.

    Resetting transcription factor control circuitry towards ground state pluripotency in human.
    Cell 2014; 158(6)1254–69 DOI: 10.1016/j.cell.2015.06.052

  • Mohsen-Kanson T, Hafner AL, Wdziekonski B, Takashima Y, Villageois P, Carrière A, Svensson M, Bagnis C, Chignon-Sicard B, Svensson PA, Casteilla L, Smith A and Dani C.

    Differentiation of human induced pluripotent stem cells into brown and white adipocytes: Role of Pax3.
    Stem Cells 2014; 32(6)1459-67 doi.org/10.1002/stem.1607

  • Kojima G, Ishida K, Takashima Y, Kurata H, Sasae R, Takaya Y.

    Rhabdomyolysis-induced transient cold urticaria.
    Ann Allergy Asthma Immunol 2014; 113(5)572-4
2013

  • Stricker S, Feber A, Engstrom PG, Caren H, Kurian KM, Takashima Y, Watts C, Way M, Dirks P, Bertone P, Smith A, Beck S, and Pollard SM.

    Widespread resetting of DNA methylation in glioblastoma-initiating cells suppresses malignant cellular behavior in a lineage-dependent manner.
    Genes and Dev 2013; 27(6)654–69
2012

  • Falk A, Koch P, Kesavan J, Takashima Y, Ladewig J, Alexander M, Wiskow O, Tailor J, Trotter T, Pollard S, Smith A, Brüstle O.

    Capture of neuroepithelial-like stem cells from pluripotent stem cells provides a versatile system for in vitro production of human neurons.
    PLOS ONE 2012; 7e29597

  • Camnasio S, Carri DA, Lombardo A, Grad I, Mariotti C, Castucci A, Rozell B, Riso PL, Castiglioni V, Zuccato C, Rochon C, Takashima Y, Diaferia G, Biunno I, Gellera C, Jaconi M, Smith A, Hovatta O, Naldini L, Donato SD, Feki A, Cattaneo E.

    The first reported generation of several induced pluripotent stem cell lines from homozygous and heterozygous Huntington's disease patients demonstrates mutation related enhanced lysosomal activity.
    Neurobiol Dis 2012; 46(1)41-51
2011

  • Nagare T, Sakaue H, Matsumoto M, Cao Y, Inagaki K, Sakai M, Takashima Y, Nakamura K, Mori T, Okada Y, Matsuki Y, Watanabe E, Ikeda K, Taguchi R, Kamimura N, Ohta S, Hiramatsu R, Kasuga M.

    Overexpression of KLF15 Transcription Factor in Adipocytes of Mice Results in Down-regulation of SCD1 Protein Expression in Adipocytes and Consequent Enhancement of Glucose-induced Insulin Secretion.
    J Biol Chem. 2011; 286(43)37458-69
2010

  • Moretti A, Bellin M, Jung CB, Thies TM, Takashima Y, Bernshausen A, Schiemann M, Fischer S, Moosmang S, Smith AG, Lam JT, Laugwitz KL.

    Mouse and human induced pluripotent stem cells as a source for multipotent Isl1+ cardiovascular progenitors.
    FASEB J. 2010; 24(3)700-11

  • Zaragosi LE, Wdziekonski B, Villageois P, Keophiphath M, Maumus M, Tchkonia T, Bourlier V, Mohsen-Kanson T, Ladoux A, Elabd C, Scheideler M, Trajanoski Z, Takashima Y, Amri EZ, Lacasa D, Sengenes C, Ailhaud G, Clément K, Bouloumie A, Kirkland JL, Dani C.

    Activin a plays a critical role in proliferation and differentiation of human adipose progenitors.
    Diabetes 2010; 59(10)2513-21
2007

  • Takashima Y, Era T, Nakao K, Kondo S, Kasuga K, Smith AG, Nishikawa S.

    Neuroepithelial cells supply an initial transient wave of MSC differentiation.
    Cell 2007; 129(7)1377 -88

  • Hikichi T, Wakayama S, Mizutani E, Takashima Y, Kishigami S, Van Thuan N, Ohta H, Bui HT, Nishikawa SI, Wakayama T.

    Differentiation Potential of Parthenogenetic Embryonic Stem Cells is Improved by Nuclear Transfer.
    Stem Cells. 2007; 25(1)46-53
2005

  • Mori T, Sakaue H, Iguchi H, Gomi H, Okada Y, Takashima Y, Nakamura K, Nakamura T, Yamauchi T, Kubota N, Kadowaki T, Matsuki Y, Ogawa W, Hiramatsu R, Kasuga M.

    Role of Kruppel-like factor 15 (KLF15) in transcriptional regulation of adipogenesis.
    J Biol Chem. 2005; 280(13)12867-75
2003

  • Sakaue H, Nishizawa A, Ogawa W, Teshigawara K, Mori T, Takashima Y, Noda T, Kasuga M.

    Requirement for 3-phosphoinositide-kependent dinase-1 (PDK-1) in insulin-induced glucose uptake in immortalized brown adipocytes.
    J Biol Chem. 2003; 278(40)38870-4
2002

  • Takashima Y*, Koide M, Fukunaga H, Iwai M, Miura M, Yoneda R, Fukuda T, Kobayashi K, Saheki T.

    Recovery from marked altered consciousness in a patient with adult-onset type II citrullinemia diagnosed by DNA analysis and treated with a living related partial liver transplantation.
    Intern Med. 2002; 41(7)555-60

著作物

2024

  • 大久保 巧,  髙島　康弘

    実験医学6月号
    「実験医学」2024 6月号
2021

  • 大久保 巧，髙島 康弘

    多能性幹細胞を用いた着床期ヒト胚モデルの構築
    「実験医学」2021 Vol.39 No.18
2018

  • 髙島 康弘, 蝉 克憲, 上田 舞

    ヒトナイーブ型ES/iPS細胞の性質と展開、細胞
    「細胞」2018 Vol.50 No.7 363-366
2017

  • 上田 舞, 髙島 康弘

    多能性幹細胞の歴史とヒトナイーブ型多能性幹細胞
    「Cytometry Research」2017 27巻 1号19-24
2016

  • 髙島 康弘、山中 伸弥

    iPS細胞の樹立とあらたな生命科学の開拓
    「医学のあゆみ」2016 Vol.257 No.13 1333-1336

  • 髙島 康弘

    iPS細胞を用いた生活習慣病の解明と治療への応用
    「Clinical CALCIUM」2016 Vol.26 No.393-99
2015

  • 髙島 康弘

    エピブラスト
    「再生医療用語ハンドブック」2015
2014

  • 髙島 康弘

    ２つの多能性幹細胞―ナイーブ型とプライム型
    「生物の科学　遺伝」2014 Vol.68 No.1
2013

  • 髙島 康弘

    ナイーブ型ES/iPS細胞―無垢なる生命のはじまりから再生医学―The Frontiers in Life Sciences
    「幹細胞研究と再生医療(中内啓光編)」2013 43-53
2009

  • 阪上　浩, 髙島 康弘

    Adipocyte proliferation and differentiation: molecular aspects and regulatory factors
    「日本臨床」2009 67(2)222-7
2008

  • 髙島 康弘

    脂肪細胞の発生とその追跡
    「The Lipid」2008 Vol.19 No.185-89
2004

  • 髙島 康弘，阪上 浩

    脂肪細胞の発生と再生
    「アディポサイエンス」2004 Vol.1 No.2124-129